Editorial Expression of Concern: Functional proteomic identification of DNA replication proteins by induced proteolysis <i>in vivo</i>

Nature published an editorial expression of concern on June 3, 2026, regarding the research paper "Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo." The concern centers on the methodology and findings presented in the study, which aimed to identify DNA replication proteins using induced proteolysis in vivo. The journal's editorial board has initiated a review process to thoroughly investigate the issues raised. This expression of concern does not necessarily imply misconduct but highlights potential problems that warrant further scrutiny before the scientific community fully accepts the paper's conclusions. The specific details of the concern have not been fully disclosed publicly, but such expressions typically involve questions about data integrity, experimental reproducibility, or the interpretation of results. Nature is committed to upholding the highest standards of scientific integrity and will provide updates as the investigation progresses. The paper's DOI is 10.1038/s41586-026-10727-w.