C-glycoside synthesis via radical cross-coupling of glycohydrazides

Researchers developed a novel method for C-glycoside synthesis on June 22, 2026, utilizing a radical cross-coupling reaction involving glycohydrazides. This new approach offers a more efficient and versatile pathway to create C-glycosides, which are important carbohydrate derivatives with applications in pharmaceuticals and materials science. The study, published in Nature, details how the radical coupling mechanism allows for the formation of a carbon-carbon bond between the anomeric carbon of a sugar and a carbon-based radical. This circumvents limitations of traditional glycosylation methods that often form less stable carbon-oxygen bonds. The team demonstrated the broad applicability of their method by synthesizing a range of C-glycosides with varying sugar moieties and coupling partners. The reaction conditions were optimized to achieve high yields and stereoselectivity, making it a practical tool for synthetic chemists. This advancement is expected to accelerate the discovery and development of new molecules containing C-glycosidic linkages.